Senior Oligonucleotide Chemist


The Role

Our exciting and collaborative client is looking for a highly motivated Senior Oligonucleotide Chemist to join their research team at their site in Oxford.

In this exciting and challenging role, the candidate will establish new oligonucleotide synthesis capabilities aimed at research and development within a newly established oligonucleotide facility.

The successful candidate will take on a technical and managerial leadership role and work closely with other members of the oligonucleotide facility team. The candidate will set up synthesis, purification, and analytical methodologies for a wide range of critical long and modified DNA/RNA oligonucleotides. In addition, the candidate will play a collaborative role in the decision-making of strategic objectives that influence future projects, the team, and the company.

Tasks include:

  • Setting up an oligonucleotide synthesis pipeline to serve critical R&D projects.
  • Developing synthesis methodologies for complex, modified and long DNA/RNA oligonucleotides.
  • Setting up the purification and analytical workflows for synthesised oligonucleotides, with automation where possible.
  • Analysing oligonucleotides by high-resolution CE, LC-MS and HPLC.
  • Onboarding new technology and methods to operational effectiveness.
  • Scientific and technical training of a team of scientists.
  • Maintaining a safe working environment for all team members and a culture of continuous improvement for health & safety.
  • Preparing clearly articulated progress reports and maintaining well-organised records.
  • Working and communicating effectively across a number of research and development groups.

Experience & Skills Required

  • BSc, MSc, or PhD degree in chemistry with industrial experience preferred.
  • Extensive experience in oligonucleotide synthesis.
  • Practical knowledge of oligonucleotide analysis and purification.
  • Experience setting up new laboratory equipment would be advantageous.
  • Experience technically leading a team of scientists would be advantageous.
  • Strong problem-solving and analytical skills.
  • Strong attention to detail and a high level of organisation.

Key Points & Benefits

  • Attractive bonus scheme
  • Generous pension contributions
  • Private Healthcare
  • Based in a beautiful working environment